Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure ethiology and correlates to clinical variables
نویسندگان
چکیده
Fermí Montó, Eduardo Oliver, Diana Vicente, Joaquín Rueda, Jaime Agüero, Luis Almenar, Maria Dolores Ivorra, Domingo Barettino, and Pilar D’Ocon Departamento de Farmacología. Facultad de Farmacia. Universitat de València. Valencia, Spain; Servicio de Cardiología. Hospital La Fe, Valencia, Spain; and Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas, Valencia, Spain
منابع مشابه
Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure etiology and correlates to clinical variables.
Downregulation of β(1)- adrenergic receptors (β(1)-ARs) and increased expression/function of G-protein-coupled receptor kinase 2 (GRK2) have been observed in human heart failure, but changes in expression of other ARs and GRKs have not been established. Another unresolved question is the incidence of these compensatory mechanisms depending on heart failure etiology and treatment. To analyze the...
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